Published Journals

Chin-Han Wu, Chia-Hua Liang, Li-Yen Shiu, Li-Ching Chang, Tsai-Shiuan Lin (2011) Solanum incanum extract (SR-T100) induces human cutaneous squamous cell carcinoma apoptosis through modulating tumor necrosis factor receptor signaling pathway J. Dermatol. 63,83-92
Shiu, L.Y., Liang, C.H., Chang, L.C., Sheu, H.M., Tsai, E.M., Kuo, K.W.* (2009) Solamargine induces apoptosis and enhances susceptibilities to trastuzumab and epirubicin in breast cancer cells with low- or high-expressing HER2/neu. Bioscience Reports 29, 35-45. SCI
Shiu, L.Y., Liang, C.H., Huang, Y.S., Sheu, H.M., Kuo, K.W.* (2008) Down-Regulation of HER2/neu Receptor by Solamargine Enhances Anticancer Drug-mediated Cytotoxicity in Breast Cancer Cells with High-expressing HER2/neu. Cell Biology and Toxicology 24, 1-10. SCI

Liang, C.H., Shiu, L.Y., Chang, L.C., Sheu, H.M., Kuo, K.W.* (2007) Solamargine enhances HER2 expression and increases the susceptibility of human lung cancer cells to trastuzumab and epirubicin. Chemical Research in Toxicology 21, 393-399. SCI

Liang, C.H., Shiu, L.Y., Chang, L.C., Sheu, H.M., Kuo, K.W.* (2007) Solamargine upregulation of Fas, downregulation of HER2 and enhancement of cytotoxicity using epirubicin in NSCLC cells. Molecular Nutrition and Food Research 51, 999 – 1005.
Shiu, L.Y., Liang, C.H., Huang, Y.S., Sheu, H.M., Kuo, K.W.* (2007) Solamargine induces apoptosis and sensitizes breast cancer cells to cisplatin. Food and Chemical Toxicology 45, 2155–2164. SCI
Liu, L.F., Liang, C.H., Shiu, L.Y., Lin, W.L., Lin, C.C., Kuo, K.W.* (2004) Action of Solamargine on Human Lung Cancer Cells-Enhancement of the Susceptibility of Cancer cells to TNFs. FEBS Lett. 577, 67-74. SCI

Liang, C.H., Liu, L.F., Shiu, L.Y., Huang, Y.S., Chang, L.C., Kuo, K.W.* (2004) Action of Solamargine on TNFs and Cisplatin-resistant Human Lung Cancer Cells. Biochem. Biophys. Res. Commun. 322, 751-758. SCI

Kuo, K.W.*, Hsu, S.H., Li, Y.P., Lin, W.L., Liu, L.F., Chang, L.C., Lin, C.C., Lin, C.N. and Sheu, H.M. (2000) Anticancer Activity Evaluation of the Solanum Glycoalkaloid Solamargine. Triggering Apoptosis in Human Hepatoma Cells. Biochem. Pharmacol. 60, 1865-1873. SCI
Chang, L.C., Tsai, T.R., Wang, J.J., Lin, C.N. and Kuo, K.W.* (1998) The Rhamnose Moiety of Solamargine Plays a Crucial Role in Triggering Cell Death by Apoptosis. Biochem. Biophys. Res. Commun. 242, 21-25. SCI 
Hsu, S.H., Tsai, T.R., Lin, C.N., Yen, M.H. and Kuo, K.W.* (1996) Solamargine purified from Solanum incanum Chinese Herb Triggers Gene Expression of Human TNFR I Which May Lead to Cell Apoptosis. Biochem. Biophys. Res. Commun. 229, 1-5.